Germ Cell Tumors of the Ovary

by / Friday, 24 September 2010 / Published in Pathology

GERM CELL TUMORS OF THE OVARY

TERATOMA – up to 90% of germ cell tumors of the ovary.  Contains all three germ layers (ectoderm, endoderm, mesoderm).  The immature teratoma is very aggressive and malignant.

DYSGERMINOMA – is the most common type of malignant germ cell ovarian tumor, usually occurring in adolescence and early life.  Is analogous to the male seminoma.

YOLK SAC TUMOR – produces a-fetoprotein

CHORIOCARCINOMA – is the same as the testicular version of the germ cell tumor, causes an increase in hCG.

NON-GERM CELL TUMORS OF THE OVARY

SEROUS CYSTADENOMA – is benign, comprises 20% of ovarian tumors and is frequently bilateral.  Is lined with fallopian tube-like epithelium.

SEROUS CYSTADENOCARCINOMA – comprises 50% of ovarian tumors, is frequently bilateral and is malignant.

MUCINOUS CYSTADENOMA – is benign, and is a multilocular cyst lined by mucus-secreting epithelium.

MUCINOUS CYSTADENOCARCINOMA – is malignant, with intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor.

BRENNER TUMOR – is a benign tumor resembling bladder epithelium.

OVARIAN FIBROMA – contains bundles of spindle-shaped fibroblasts.  “Meig’s syndrome” is a triad of ovarian fibroma, ascites, and hydrothorax.

GRANULOSA CELL TUMOR – secretes estrogen causing precocious puberty in children, while in adults it can cause endometrial hyperplasia or carcinoma.  Contains “Call-Exner bodies”, which are small follicles filled with eosinophilic secretions.

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