Receptors of the sympathetic nervous system

by / Friday, 20 August 2010 / Published in Pharmacology

THE a1 RECEPTOR

AGONISTS ANTAGONISTS AGONIST POTENCY MECHANISM OF ACTION
Norepinephrine

Phenylephrine

Methoxamine

Xylometazoline

Prazosin

Terazosin

Doxazosin

Alfuzosin

Phenoxybenzamine

Phentolamine

NE > EPI Gq: Phospholipase C activated, IP3 and Calcium.

THE a2 RECEPTOR

AGONISTS ANTAGONISTS AGONIST POTENCY MECHANISM OF ACTION
Clonidine

Brimonidine

Phentolamine

Yohimbine

Atipamezole

EPI > NE Gi: AC inactivated, cAMP

THE b1 RECEPTOR

AGONISTS ANTAGONISTS AGONIST POTENCY MECHANISM OF ACTION
Dobutamine Metoprolol

Atenolol

Isoprenaline > EPI = NE Gs: AC activated, cAMP

THE b2 RECEPTOR

AGONISTS ANTAGONISTS AGONIST POTENCY MECHANISM OF ACTION
Albuterol

Isoprenaline

Metaproterenol

Salmetrol

Terbutaline

Propranolol Isoprenaline > EPI >> NE Gs: AC activated, cAMP

Leave a Reply

TOP