Recurrent Spontaneous Abortions – USMLE Step 2 CK exam
A patient who presents with recurring spontaneous abortion is highly suspicious of having LUPUS.
What is the reason for this?
ANTIPHOSPHOLIPID ANTIBODIES are present in some SLE patients. These antibodies are associated with both arterial and venous thromboembolic disease.
There is an association between antiphospholipid antibody and recurring fetal loss after 10 weeks gestation. This causes thrombus development within the placenta.
Other important facts:
- Vasospasm is teh primary pathophysiological cause of pre-eclampsia
- Chromosomal abnormality can be a cause of 1st trimester abortions
- DIC is a complication in patients who had a septic abortion, but is a consequence (not the cause).
- Infections can be a reason for a loss of pregnancy, but usually only a single pregnancy
- Congenital heart block is complication in children with mother’s who have SLE
- Cervical incompetence is a cause of mid-trimester abortions