SOME FACTS ABOUT ERYTHROPOIESIS

by / Wednesday, 23 February 2011 / Published in Emryology

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– begins in the yolk sac at 4mnth of gestation

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– at 6 months of gestation, it moves into the liver, flat bones, and the spleen.

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– at 8 mnth of gestation, it moves into the long bones.

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* a child with sickle cell before 1yr of age, you’ll see their head enlarge, spleen get big, etc

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** if you ever lose your long bones, the spleen will take over and you’ll get massive splenomegaly.

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***** If you ever see someone with massivesplenomegaly, always think of problems that eliminate bone marrow production (vinblastine, chloramphenicol, AZT, benzene)

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Virus that can wipe out BM –> parvo B19

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Bone disease wiping out BM –> osteopetrosis (decreased osteoclastic activity – no bone broken down, obliterates BM).

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