Surgical Conditions of the Gallbladder – USMLE CK

by / Wednesday, 16 June 2010 / Published in Internal Medicine, Surgery

Surgical Conditions of the Gallbladder

Gallstones (Cholelithiasis)

Seen mostly in women with the 4 F’s

  1. Female
  2. Fat
  3. Forty
  4. Fertile


  • It isn’t the presence of gallstones that warrants intervention, but the possible complications associated with them
  • Ultrasound is the test of choice for identifying gallstones



  • Asymptomatic gallstones require no intervention
  • Chronic pain may require a cholecystectomy
  • With an increased risk of cancer, such as in the case of a calcified gallbladder wall, cholecystectomy may be warranted


  • Is an infection of the gallbladder that is a result of an obstruction
  • Common causes are: E. Coli, Enterobacter, Enterococcus, and Klebsiella

Note the shadow from the impacted stone.

Signs and Symptoms:

  • Acute onset of right upper quadrant pain that is non-remitting
  • (+) Murphy’s sign – arrest of inspiration upon palpation


  • Ultrasound to detect stones, a thickened wall, or fluid surrounding the GB
  • Confirm with HIDA scan
  • Labs show WBC’s >20,000, Ý Bilirubin, Ý AST/ALT



  • Keep patient NPO, give IV fluids, and give antibiotics to cover gram (-) rods and anaerobes
  • Do not give morphine for pain because it causes a spasm of the sphincter of oddi
  • If improvements are not seen, cholecystectomy may be warranted


Ascending Cholangitis

  • Obstructed bile flow from an obstructed common bile duct leads to an infection
  • Presence of Charcot’s triad:  RUQ, fever, jaundice is commonly seen



  • Ultrasound to detect dilation
  • An ERCP can be used after the preliminary US diagnosis


  • NPO
  • IV fluids
  • Gram (-) antibiotics
  • ERCP for decompression of the biliary tree and for removal of the stones



  • An obstruction of the common bile duct

Signs and Symptoms:

  • Jaundice (obstructive)
  • Increased Alkaline phosphatase
  • Increased Conjugated bilirubin


  • Ultrasound to detect CBD obstruction



  • Cholecystectomy


Cancer of the GB

  • Is a rare cancer that is associated with a history of gallstones
  • Occurs later in life
  • The MC primary tumor of the gallbladder is the adenocarcinoma
  • Associated with Clonorchis sinensis infestation
  • Has a grave prognosis, with most patients dying within 1yr of diagnosis


Signs and Symptoms:

  • Sharp, colicky pain


  • US or CT to detect the tumor


  • Placement of bile duct stents
  • Surgery as a palliative option, but is not curative


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