The Pharmacology of Parkinson’s Disease
Parkinson’s disease results from the degeneration of dopamine (DA) neurons in the substantia nigra. Symptoms are resting tremor, rigidity, and bradykinesia.
Dopamine cannot cross the blood-brain barrier, thus it is converted to levedopa in order to get across the BBB. There are certain drugs that can be used in order to prevent the conversion of levedopa to other things that cannot cross.
Dopamine Receptor Agonists:
Bromocriptine – An ergot alkaloid, a D2 agonist and D1 antagonist.
Pergolide – D1 and D2 antagonist, can cause neurological symptoms.
Ropinorole – The drug of choice for restless leg syndrome.