Types of Renal Tubular Acidosis

by / Wednesday, 30 June 2010 / Published in Internal Medicine


Renal Tubular Acidosis:

Type Characteristic Urinary pH
Type I A defect of the distal tubule (H+ gradient) >5.5
Type II Proximal tubule fails to resorb HCO3 >5.5 early then <5.5 as the acidosis worsens
Type IV Decr Aldosterone (leading to hyper K+ and hyper Cl-

From decr secretion seen in DM, interstitial nephritis, ACEI’s, heparin, and NSAID use.

May also be due to aldosterone resistance from sickle cell or urinary obstruction



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